Het-PDB Navi2 (PDB: 4Z6A)

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Ligands
Code	Name	Link
0Z6	D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide	PoSSuM
CA	Calcium ion	PoSSuM
CIT	Citric acid	PoSSuM
BGC	Beta-D-glucopyranose	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
FUC	Alpha-L-fucopyranose

Modification
Code	Name	Show

Download interaction data: 4Z6A

Code :

4Z6A PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal Structure of a FVIIa-Trypsin Chimera (YT) in Complex with Soluble Tissue Factor

Release Data :

2015-12-30

Compound :

mol_id	molecule	chains	synonym
1	Coagulation factor VII	L	Proconvertin,Serum prothrombin conversion accelerator,SPCA
	ec: 3.4.21.21 fragment: UNP residues 108-203

mol_id	molecule	chains	synonym
2	Coagulation factor VII	H	Proconvertin,Serum prothrombin conversion accelerator,SPCA
	ec: 3.4.21.21 fragment: unp residues 213-465 mutation: [169-175] LQQSRKVGDSPN - EASYPGK

mol_id	molecule	chains	synonym
3	Tissue factor	T	TF,Coagulation factor III,Thromboplastin
	fragment: unp residues 36-242

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Cricetulus griseus (taxid:10029)
	organ: Kidney tissue: Blood gene: F7 expression_system_common: Chinese hamster expression_system_cell_line: CHOEBNALT85 expression_system_vector_type: plasmid expression_system_plasmid: pQMCF-5

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Cricetulus griseus (taxid:10029)
	organ: Kidney tissue: Blood gene: F7 expression_system_common: Chinese hamster expression_system_cell_line: CHOEBNALT85 expression_system_vector_type: plasmid expression_system_plasmid: pQMCF-5

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	tissue: Blood gene: F3 expression_system_common: Chinese hamster expression_system_strain: Origami 2 expression_system_vector_type: plasmid expression_system_plasmid: pET3a

Authors :

Sorensen, A.B., Svensson, L.A., Gandhi, P.S.

Keywords :

trypsin-fold, protein-protein complex, hydrolase

Exp. method :

X-RAY DIFFRACTION ( 2.2500 Å )

Citation :

Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.

Sorensen, A.B.,Madsen, J.J.,Svensson, L.A. et al.
(2016) J.Biol.Chem. 291 : 4671 - 4683

PubMed: 26694616
DOI: 10.1074/jbc.M115.698613

Chain :

UniProt :

P08709 (FA7_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Ile bond in factor X to form factor Xa.	3.4.21.21	-
	-	-

Chain :	T
UniProt :	P13726 (TF_HUMAN)
Reaction :	-

PDB ID: 4Z6A

Hetero Atom Contents

Structure summary

Reaction