Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0RW 3-methyl-2h-indazole
Modified Residues
Code Name Link
SEP Phosphoserine
TPO Phosphothreonine
Code : 4YXR
Header : TRANSFERASE
Title : CRYSTAL STRUCTURE OF PKA IN COMPLEX WITH inhibitor.
Release Data : 2015-05-27
Compound :
mol_id molecule chains synonym
1 cAMP-dependent protein kinase catalytic subunit alpha A PKA C-alpha
ec: 2.7.11.11
other_details: ALPHA ISOENZYME
mol_id molecule chains synonym
2 cAMP-dependent protein kinase inhibitor alpha I PKI-alpha
other_details: ALPHA ISOENZYME
Source :
mol_id organism_scientific organism_common expression_system
1 Bos taurus  (taxid:9913) Bovine Escherichia coli  (taxid:562)
gene: PRKACA
mol_id organism_scientific organism_common expression_system
2 Bos taurus  (taxid:9913) Bovine Escherichia coli  (taxid:562)
gene: PKIA
Authors : Schiffer, A., Wendt, K.U.
Keywords : COMPLEX (PHOSPHOTRANSFERASE-INHIBITOR) complex, transferase
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles.

Pilger, J.,Mazur, A.,Monecke, P.  et al.
(2015)  Angew.Chem.Int.Ed.Engl.  54 : 6511 - 6515

PubMed: 25877959
DOI: 10.1002/anie.201500671

Chain : A
UniProt : P00517 (KAPCA_BOVIN)
Reaction : ATP + a protein = ADP + a phosphoprotein.
Chain : I
UniProt : Q3SX13 (IPKA_BOVIN)
Reaction : -