Brand  (β version)

PDB ID: 4YXD

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Ligands
Code Name Style Show Link
F3S Fe3-s4 cluster PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
FTN N-[3-(1-methylethoxy)phenyl]-2-(trifluoromethyl)benzamide PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
SF4 Iron/sulfur cluster PoSSuM
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Structure summary

Code : 4YXD   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title : CRYSTAL STRUCTURE OF PORCINE HEART MITOCHONDRIAL COMPLEX II BOUND WITH flutolanil
Release Data : 2016-03-02
Compound :
mol_id molecule chains synonym
1 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial A Flavoprotein subunit of complex II,Fp
ec: 1.3.5.1
mol_id molecule chains synonym
2 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial B Iron-sulfur subunit of complex II,Ip
ec: 1.3.5.1
mol_id molecule chains synonym
3 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial C Succinate-ubiquinone oxidoreductase cytochrome B large subunit,CYBL
mol_id molecule chains synonym
4 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial D CybS,CII-4,QPs3,Succinate dehydrogenase complex subunit D,Succinate-ubiquinone oxidoreductase cytochrome b small subunit,Succinate-ubiquinone reductase membrane anchor subunit
Source :
mol_id organism_scientific organism_common
1 Sus scrofa  (taxid:9823) Pig
mol_id organism_scientific organism_common
2 Sus scrofa  (taxid:9823) Pig
mol_id organism_scientific organism_common
3 Sus scrofa  (taxid:9823) Pig
mol_id organism_scientific organism_common
4 Sus scrofa  (taxid:9823) Pig
Authors : Harada, S., Shiba, T., Sato, D., Yamamoto, A., Nagahama, M., Yone, A., Inaoka, D.K., Sakamoto, K., Inoue, M., Honma, T., Kita, K.
Keywords : OXIDOREDUCTASE, SUCCINATE DEHYDROGENASE, Complex II, Inhibitor, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria

Inaoka, D.K.,Shiba, T.,Sato, D.  et al.
(2015)  Int J Mol Sci  16 : 15287 - 15308

PubMed: 26198225
DOI: 10.3390/ijms160715287

Reaction

Chain : A
UniProt : Q0QF01 (SDHA_PIG)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = a quinol + fumarate 1.3.5.1 PubMed:15989954
-
Chain : B
UniProt : Q007T0 (SDHB_PIG)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = a quinol + fumarate 1.3.5.1 UniProtKB:P21912
-
Chain : C
UniProt : D0VWV4 (C560_PIG)
Reaction : -
Chain : D
UniProt : A5GZW8 (DHSD_PIG)
Reaction : -