Brand  (β version)

PDB ID: 4YT1

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Ligands
Code Name Style Show Link
JJB N-(benzylsulfonyl)-4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)benzamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4YT1   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Human PPAR Gamma Ligand Binding Domain in complex with a Gammma Selective Synthetic Partial Agonist MEKT76
Release Data : 2016-03-02
Compound :
mol_id molecule chains synonym
1 Peroxisome proliferator-activated receptor gamma A,B PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
fragment: ligand binding domain, UNP residues 223-504
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: PPARG, NR1C3
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Oyama, T., Ohashi, M., Miyachi, H., Kusunoki, M.
Keywords : NUCLEAR RECEPTOR, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Peroxisome proliferator-activated receptor gamma (PPAR gamma ) has multiple binding points that accommodate ligands in various conformations: Structurally similar PPAR gamma partial agonists bind to PPAR gamma LBD in different conformations

Ohashi, M.,Gamo, K.,Oyama, T.  et al.
(2015)  Bioorg.Med.Chem.Lett.  25 : 2758 - 2762

PubMed: 26025876
DOI: 10.1016/j.bmcl.2015.05.025

Reaction

Chain : A, B
UniProt : P37231 (PPARG_HUMAN)
Reaction : -