Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CA Calcium ion
0Z7 N-acetyl-D-phenylalanyl-N-[(2s,3s)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide
BGC Beta-D-glucose
FUC Alpha-L-fucose
POL N-propanol
TMA Tetramethylammonium ion
XYS Xylopyranose
Modified Residues
Code Name Link
CGU Gamma-carboxy-glutamic acid
Code : 4YLQ
Header : HYDROLASE
Title : Crystal Structure of a FVIIa-Trypsin Chimera (FT) in Complex with Soluble Tissue Factor
Release Data : 2015-12-30
Compound :
mol_id molecule chains synonym
1 Coagulation factor VII L Proconvertin,Serum prothrombin conversion accelerator,SPCA
ec: 3.4.21.21
fragment: BLOOD COAGULATION FACTOR VIIA LIGHT CHAIN, UNP residues 61-212
mol_id molecule chains synonym
2 Coagulation factor VII H Proconvertin,Serum prothrombin conversion accelerator,SPCA
ec: 3.4.21.21
fragment: UNP residues 213-466
mutation: [169-175] LQQSRKVGDSPN - EASFPGK
mol_id molecule chains synonym
3 Tissue factor T TF,Coagulation factor III,Thromboplastin
fragment: UNP residues 33-251
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
organ: Kidney
tissue: Blood
gene: F7
expression_system_common: Chinese Hamster
expression_system_cell_line: CHOEBNALT85
expression_system_vector_type: plasmid
expression_system_plasmid: pQMCF-5
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
organ: Kidney
tissue: Blood
gene: F7
expression_system_common: Chinese Hamster
expression_system_cell_line: CHOEBNALT85
expression_system_vector_type: plasmid
expression_system_plasmid: pQMCF-5
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
tissue: Blood
gene: F3
expression_system_variant: Origami 2
expression_system_vector_type: plasmid
expression_system_plasmid: pET3a
Authors : Sorensen, A.B., Svensson, L.A., Gandhi, P.S.
Keywords : trypsin-fold, protein-protein complex, hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.4000 Å )
Citation :

Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.

Sorensen, A.B.,Madsen, J.J.,Svensson, L.A.  et al.
(2016)  J.Biol.Chem.  291 : 4671 - 4683

PubMed: 26694616
DOI: 10.1074/jbc.M115.698613

Chain : H
UniProt : P08709 (FA7_HUMAN)
Reaction : Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Chain : T
UniProt : P13726 (TF_HUMAN)
Reaction : -