Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
98 (4r)-4-methyl-1,3,4,5-tetrahydro-2h-1,5-benzodiazepin-2-one
EDO 1,2-ethanediol
Code : 4YK0
Header : TRANSFERASE
Title : Crystal structure of the CBP bromodomain in complex with CPI098
Release Data : 2016-04-20
Compound :
mol_id molecule chains
1 CREB-binding protein A,B,C,D
ec: 2.3.1.48
fragment: bromodomain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CREBBP, CBP
expression_system_vector_type: plasmid
Authors : Bellon, S.F., Jayaram, H.
Keywords : CBP, CPI098, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.6500 Å )
Citation :

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.

Ghosh, S.,Taylor, A.,Chin, M.  et al.
(2016)  J.Biol.Chem.  291 : 13014 - 13027

PubMed: 27056325
DOI: 10.1074/jbc.M115.708560

Chain : A, B, C, D
UniProt : Q92793 (CBP_HUMAN)
Reaction : Acetyl-CoA + [histone] = CoA + acetyl- [histone].