Brand  (β version)

PDB ID: 4Y7A

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Ligands
Code Name Style Show Link
987 N-[(3s)-1-{(2s)-1-[(3s)-3-aminopiperidin-1-yl]-1-oxopropan-2-yl}-2-oxopyrrolidin-3-yl]-6-chloronaphthalene-2-sulfonamid E PoSSuM
CA Calcium ion PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4Y7A   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Factor Xa complex with GTC000422
Release Data : 2015-09-30
Compound :
mol_id molecule chains synonym
1 Coagulation factor X A Stuart factor,Stuart-Prower factor, Activated factor Xa heavy chain
ec: 3.4.21.6
mol_id molecule chains synonym
2 Coagulation factor X B Stuart factor,Stuart-Prower factor, Factor X light chain
ec: 3.4.21.6
fragment: UNP residues 46-179
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
Authors : Convery, M.A., Young, R.J., Senger, S., Hamblin, J.N., Chan, C., Toomey, J.R., Watson, N.S.
Keywords : Hydrolase, Inhibitor
Exp. method : X-RAY DIFFRACTION ( 1.9900 Å )
Citation :

Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides.

Chan, C.,Borthwick, A.D.,Brown, D.  et al.
(2007)  J. Med. Chem.  50 : 1546 - 1557

PubMed: 17338508
DOI: 10.1021/jm060870c

Factor Xa complex with GTC000422

Convery, M.A.,Young, R.J.,Senger, S.  et al.
to be published 

Reaction

Chain : B
UniProt : P00742 (FA10_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin. 3.4.21.6 -
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