Brand  (β version)

PDB ID: 4Y49

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Ligands
Code Name Style Show Link
G4P Guanosine-5',3'-tetraphosphate PoSSuM
CMC Carboxymethyl coenzyme *a PoSSuM
ACO Acetyl coenzyme *a PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4Y49   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of yeast N-terminal acetyltransferase (ppGpp) NatE in complex with a bisubstrate
Release Data : 2016-07-13
Compound :
mol_id molecule chains synonym
1 N-terminal acetyltransferase A complex subunit NAT1 A,G,M NatA complex subunit NAT1,Amino-terminal,alpha-amino,acetyltransferase 1
mol_id molecule chains synonym
2 N-terminal acetyltransferase A complex catalytic subunit ARD1 B,H,N NatA complex subunit ARD1,Arrest-defective protein 1
ec: 2.3.1.88
mol_id molecule chains synonym
3 N-terminal acetyltransferase A complex subunit NAT5 C,I,O NatA complex subunit NAT5
ec: 2.3.1.-
mol_id molecule chains
4 ALA-ALA-ALA-ALA-ALA-ALA E,K,Q
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast Escherichia coli  (taxid:562)
mol_id organism_scientific organism_common expression_system
2 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast Escherichia coli  (taxid:562)
mol_id organism_scientific organism_common expression_system
3 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast Escherichia coli  (taxid:562)
mol_id organism_scientific organism_common
4 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Dong, J., Wang, S., York, J.D.
Keywords : N-terminal acetyltransferase, NatE, ppGpp, bisubstrate, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 3.95 Å )
Citation :

Crystal structure of yeast N-terminal acetyltransferase (ppGpp) NatE in complex with a bisubstrate

Dong, J.,Wang, S.,York, J.D.
To Be Published 

Reaction

Chain : A, G, M
UniProt : P12945 (NAT1_YEAST)
Reaction : -
Chain : B, H, N
UniProt : P07347 (ARD1_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetylglycyl-[protein] 2.3.1.255 PubMed:1600941, PubMed:2551674
-
acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-alanyl-[protein] 2.3.1.255 PubMed:1600941, PubMed:2551674
-
acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-seryl-[protein] 2.3.1.255 PubMed:1600941, PubMed:2551674
-
acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-valyl-[protein] 2.3.1.255 PubMed:1600941, PubMed:2551674
-
acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] 2.3.1.255 PubMed:1600941, PubMed:2551674
-
acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-threonyl-[protein] 2.3.1.255 PubMed:1600941, PubMed:2551674
-
Chain : C, I, O
UniProt : Q08689 (NAT5_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] 2.3.1.258 PubMed:25886145
-
acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] 2.3.1.258 PubMed:25886145
-
acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] 2.3.1.258 PubMed:25886145
-
acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] 2.3.1.258 PubMed:25886145
-
acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] 2.3.1.258 PubMed:25886145
-
acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] 2.3.1.258 PubMed:25886145
-
acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl- [protein] 2.3.1.258 PubMed:25886145
-
acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] 2.3.1.258 PubMed:25886145
-