Brand  (β version)

PDB ID: 4XUG

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
F9F 2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate PoSSuM
NH4 Ammonium ion PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 4XUG   PDBj   RCSB PDB   PDBe
Header : LYASE/LYASE INHIBITOR
Title : Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with 2-({[4-(Trifluoromethoxy)Phenyl]Sulfonyl}Amino)Ethyl Dihydrogen Phosphate (F9F) inhibitor in the alpha site and ammonium ion in the metal coordination site.
Release Data : 2016-01-27
Compound :
mol_id molecule chains
1 Tryptophan synthase alpha chain A
ec: 4.2.1.20
other_details: Tryptophan Synthase chain A
mol_id molecule chains
2 Tryptophan synthase beta chain B
ec: 4.2.1.20
Source :
mol_id organism_scientific expression_system
1 Salmonella enterica subsp. enterica serovar Typhimurium  (taxid:90371) Escherichia coli  (taxid:562)
gene: trpA
expression_system_strain: Cb149
expression_system_vector_type: plasmid
expression_system_plasmid: Derivative of Pbr322
mol_id organism_scientific expression_system
2 Salmonella enterica subsp. enterica serovar Typhimurium  (taxid:90371) Escherichia coli  (taxid:562)
gene: trpB
expression_system_strain: Cb149
expression_system_vector_type: plasmid
expression_system_plasmid: Derivative of Pbr322
Authors : Hilario, E., Caulkins, B.G., Young, R.P., Niks, D., Dunn, M.F., Mueller, L.J., Fan, L.
Keywords : carbon-oxygen lyase, hydro-lyase, tryptophan biosynthesis, Salmonella typhimurium, F9F, inhibitor, allosteric enzyme, aromatic amino acid biosynthesis, pyridoxal phosphate, LYASE-LYASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.6500 Å )
Citation :

Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with 2-({[4-(Trifluoromethoxy)Phenyl]Sulfonyl}Amino)Ethyl Dihydrogen Phosphate (F9F) inhibitor in the alpha site and ammonium ion in the metal coordination site.

Hilario, E.,Caulkins, B.G.,Young, R.P.  et al.
To Be Published 

Reaction

Chain : A
UniProt : P00929 (TRPA_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan 4.2.1.20 HAMAP-Rule:MF_00131
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Chain : B
UniProt : P0A2K1 (TRPB_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan 4.2.1.20 -
-