Het-PDB Navi2 (PDB: 4XPB)

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Download interaction data: 4XPB

Code :

4XPB PDBj RCSB PDB PDBe

Header :

tranport protein/inhibitor

Title :

X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to cocaine

Release Data :

2015-05-13

Compound :

mol_id	molecule	chains
1	Transporter	A
	mutation: V74A, D121G, S426M

mol_id	molecule	chains
2	Antibody fragment heavy chain-protein, 9D5-heavy chain	L

mol_id	molecule	chains
3	Antibody fragment light chain-protein, 9D5-light chain	H

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Drosophila melanogaster (taxid:7227)	Fruit fly	Homo sapiens (taxid:9606)
	gene: DAT, CG8380, Dmel_CG8380 expression_system_cell_line: HEK293 GnTI

mol_id	organism_scientific	expression_system
2	Mus musculus (taxid:10090)	Mus musculus (taxid:10090)
	expression_system_cell_line: hybridoma

mol_id	organism_scientific	expression_system
3	Mus musculus (taxid:10090)	Mus musculus (taxid:10090)
	expression_system_cell_line: hybridoma

Authors :

Aravind, P., Wang, K., Gouaux, E.

Keywords :

integral membrane protein, all-alpha helical antidepressant complex, tranport protein-inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 3.05 Å )

Citation :

Neurotransmitter and psychostimulant recognition by the dopamine transporter.

Wang, K.H.,Penmatsa, A.,Gouaux, E.
(2015) Nature 521 : 322 - 327

PDB ID: 4XPB