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Ligands
Code Name Style Show Link
CL Chloride ion
CLR Cholesterol
COC Cocaine
NA Sodium ion
P4G 1-ethoxy-2-(2-ethoxyethoxy)ethane
Y01 Cholesterol hemisuccinate
GLC Alpha-D-glucopyranose
: Polysaccharide
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Code : 4XP4   PDBj   RCSB PDB   PDBe
Header : transport protein/inhibitor
Title : X-ray structure of Drosophila dopamine transporter in complex with cocaine
Release Data : 2015-05-06
Compound :
mol_id molecule chains synonym
1 Dopamine transporter A Dopamine transporter,isoform A,GH22929p
mutation: V74A, L415A
mol_id molecule chains
2 ANTIBODY FRAGMENT HEAVY CHAIN-PROTEIN, 9D5-HEAVY CHAIN L
mol_id molecule chains
3 ANTIBODY FRAGMENT HEAVY CHAIN-PROTEIN, 9D5-LIGHT CHAIN H
Source :
mol_id organism_scientific organism_common expression_system
1 Drosophila melanogaster  (taxid:7227) Fruit fly Homo sapiens  (taxid:9606)
gene: DAT, CG8380, Dmel_CG8380
expression_system_cell_line: GnTI-
mol_id organism_scientific organism_common expression_system
2 Mus musculus  (taxid:10090) Mouse Mus musculus  (taxid:10090)
mol_id organism_scientific organism_common expression_system
3 Mus musculus  (taxid:10090) Mouse Mus musculus  (taxid:10090)
Authors : Aravind, P., Wang, K., Gouaux, E.
Keywords : integral membrane protein, all-alpha helical antidepressant complex, membrane protein-tranport protein complex, transport protein-inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Neurotransmitter and psychostimulant recognition by the dopamine transporter.

Wang, K.H.,Penmatsa, A.,Gouaux, E.
(2015)  Nature  521 : 322 - 327

PubMed: 25970245
DOI: 10.1038/nature14431

Chain : A
UniProt : Q7K4Y6 (DAT_DROME)
Reaction : -