PDB ID: 4XE6
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Code | Name | Style | Show | Link | |
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06U | 6-ethyl-5-{(3r)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine | PoSSuM | |||
ACT | Acetate ion | PoSSuM | |||
NDP | Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate | PoSSuM |
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Download interaction data: 4XE6
Structure summary
Code : | 4XE6 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE/OXIDOREDUCTASE Inhibitor | ||||||||||||
Title : | Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1061) | ||||||||||||
Release Data : | 2016-01-20 | ||||||||||||
Compound : |
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Source : |
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Authors : | Reeve, S.M., Anderson, A.C. | ||||||||||||
Keywords : | Dihydrofolate reductase, Oxidoreductase, Methicillin-resistant Staphylococcus aureus, Antifolates, Enantiopure Inhibitors, OXIDOREDUCTASE-OXIDOREDUCTASE Inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.692 Å ) | ||||||||||||
Citation : |
Stereo-selectively Induced Cofactor Switching Provides Insight into Cofactor Site Plasticity as a Possible Mechanism of Antifolate Resistance
Keshipeddy, S.,Reeve, S.M.,Anderson, A.C.
et al.
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Reaction
Chain : | X | ||||||||
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UniProt : | P0A017 (DYR_STAAU) | ||||||||
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