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Ligands
Code Name Style Show Link
AKG 2-oxoglutaric acid
HY0 Hygromycin B variant
NI Nickel (II) ion
Non-standard Residues
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Glycosylation
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Modification
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Code : 4XCB   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of HygX from Streptomyces hygroscopicus with nickel, 2-oxoglutarate, and hygromycin B bound
Release Data : 2015-08-05
Compound :
mol_id molecule chains
1 oxidase/hydroxylase A,B,C,D
Source :
mol_id organism_scientific expression_system
1 Streptomyces hygroscopicus subsp. hygroscopicus  (taxid:68042) Escherichia coli  (taxid:469008)
gene: hygX
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a(+)
Authors : McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Keywords : oxidoreductase, double stranded beta helix
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.

McCulloch, K.M.,McCranie, E.K.,Smith, J.A.  et al.
(2015)  Proc.Natl.Acad.Sci.USA  112 : 11547 - 11552

PubMed: 26240321
DOI: 10.1073/pnas.1500964112

Chain : A, B, C, D
UniProt : Q2MFS1 (Q2MFS1_STRHY)
Reaction : -