Brand  (β version)

PDB ID: 4X3P

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Ligands
Code Name Style Show Link
3LX Tridecanethial PoSSuM
CNA Carba-nicotinamide-adenine-dinucleotide PoSSuM
EDO 1,2-ethanediol PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4X3P   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/PEPTIDE
Title : Sirt2 in complex with a myristoyl peptide
Release Data : 2016-01-13
Compound :
mol_id molecule chains synonym
1 NAD-dependent protein deacetylase sirtuin-2 A Regulatory protein SIR2 homolog 2,SIR2-like protein 2
ec: 3.5.1.-
fragment: UNP RESIDUES 52-355
mol_id molecule chains
2 peptide PRO-LYS-LYS-THR-GLY C
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: SIRT2, SIR2L, SIR2L2
mol_id organism_scientific
2 Homo sapiens  (taxid:9606)
synthetic: yes
Authors : Wang, Y., Zhang, W., Hao, Q.
Keywords : sirt2, myristoyl peptide, HYDROLASE-PEPTIDE complex
Exp. method : X-RAY DIFFRACTION ( 1.8000 Å )
Citation :

Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure.

Wang, Y.,Fung, Y.M.E.,Zhang, W.  et al.
(2017)  Cell Chem Biol  24 : 339 - 345

PubMed: 28286128
DOI: 10.1016/j.chembiol.2017.02.007

Reaction

Chain : A
UniProt : Q8IXJ6 (SIR2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide 2.3.1.286 PROSITE-ProRule:PRU00236, PubMed:11483616, PubMed:11812793, PubMed:16648462, PubMed:18722353, PubMed:24177535, PubMed:24389023, PubMed:24940000, PubMed:25672491
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H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O- tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide - PubMed:25704306, PubMed:32103017
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H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O- hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide - PubMed:29239724
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