Brand  (β version)

PDB ID: 4WVD

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Ligands
Code Name Style Show Link
FMT Formic acid PoSSuM
IVM (2ae,4e,5'S,6s,6'R,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2h,7h-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4WVD   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Identification of a novel FXR ligand that regulates metabolism
Release Data : 2015-02-11
Compound :
mol_id molecule chains synonym
1 Nuclear receptor corepressor 1 C,D N-CoR1
fragment: UNP residues 2259-2275
mol_id molecule chains synonym
2 Bile acid receptor A,B Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14
fragment: Ligand Binding Domain, UNP residues 244-454
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
synthetic: yes
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: NR1H4, BAR, FXR, HRR1, RIP14
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET24
Authors : Wang, R., Li, Y.
Keywords : AF-2 helix, ligand binding pocket, three-layer helical sandwich, TRANSCRIPTION REGULATOR FXR, BAR, NR1H4, bile acid receptor, NHR, nuclear receptor, corepressor, Transcription, Transcription regulation
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism.

Jin, L.,Feng, X.,Rong, H.  et al.
(2013)  Nat Commun  4 : 1937

PubMed: 23728580
DOI: 10.1038/ncomms2924

Reaction

Chain : C, D
UniProt : O75376 (NCOR1_HUMAN)
Reaction : -
Chain : A, B
UniProt : Q96RI1 (NR1H4_HUMAN)
Reaction : -