Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
MG Magnesium ion
CX8 [2-{3-[(2-{[2-(amino-kappan)ethyl]amino-kappan}ethyl)amino-kappan]propyl}-1h-benzo[de]isoquinoline-1,3(2h)-dionato(3-)]platinum
SO4 Sulfate ion
Code : 4WU9
Header : STRUCTURAL PROTEIN/DNA
Title : Structure of cisPtNAP-NCP145
Release Data : 2015-09-02
Compound :
mol_id molecule chains
1 Histone H3.2 A,E
mutation: G102A
mol_id molecule chains
2 Histone H4 B,F
mol_id molecule chains
3 Histone H2A type 1 C,G
mutation: G99R, A123S
mol_id molecule chains synonym
4 Histone H2B 1.1 D,H H2B1.1
mutation: S29T
mol_id molecule chains
5 DNA (145-MER) I
mol_id molecule chains
6 DNA (145-MER) J
Source :
mol_id organism_scientific organism_common expression_system
1 Xenopus laevis  (taxid:8355) African clawed frog Escherichia coli  (taxid:562)
mol_id organism_scientific organism_common expression_system
2 Xenopus laevis  (taxid:8355) African clawed frog Escherichia coli  (taxid:562)
mol_id organism_scientific organism_common expression_system
3 Xenopus laevis  (taxid:8355) African clawed frog Escherichia coli  (taxid:562)
mol_id organism_scientific organism_common expression_system
4 Xenopus laevis  (taxid:8355) African clawed frog Escherichia coli  (taxid:562)
mol_id organism_scientific
5 Synthetic construct  (taxid:32630)
synthetic: yes
mol_id organism_scientific
6 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Chua, E.Y.D., Davey, G.E., Chin, C.F., Droge, P., Ang, W.H., Davey, C.A.
Keywords : Nucleosome, platinum drug targeting, STRUCTURAL PROTEIN-DNA complex
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents.

Chua, E.Y.,Davey, G.E.,Chin, C.F.  et al.
(2015)  Nucleic Acids Res.  43 : 5284 - 5296

PubMed: 25916851
DOI: 10.1093/nar/gkv356

Chain : A, E
UniProt : P84233 (H32_XENLA)
Reaction : -
Chain : B, F
UniProt : P62799 (H4_XENLA)
Reaction : -
Chain : C, G
UniProt : P06897 (H2A1_XENLA)
Reaction : -
Chain : D, H
UniProt : P02281 (H2B11_XENLA)
Reaction : -