Het-PDB Navi2 (PDB: 4WJ5)

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Ligands
Code	Name		Style	Show	Link
GOL	Glycerol				PoSSuM

Non-standard Residues
Code	Name	Show
NVA	Norvaline
LPH	L-propargylglycine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
GRN	2-phenyl-L-alanine

Download interaction data: 4WJ5

Code :

4WJ5 PDBj RCSB PDB PDBe

Header :

IMMUNE SYSTEM

Title :

Structure of HLA-A2 in complex with an altered peptide ligands based on Mart-1 variant epitope

Release Data :

2014-10-29

Compound :

mol_id	molecule	chains	synonym
1	HLA class I histocompatibility antigen, A-2 alpha chain	A,D	MHC class I antigen A*2

mol_id	molecule	chains
2	Beta-2-microglobulin	B,E
	fragment: UNP residues 21-119 mutation: Methionine residue is introduced as start codon

mol_id	molecule	chains	synonym
3	Melanoma antigen recognized by T-cells 1	C,F	MART-1,Antigen LB39-AA,Antigen SK29-AA,Protein Melan-A
	other_details: DECAMERIC ALTERED PEPTIDE LIGNAD FROM THE MART-1/MELAN-A epitope EAAGIGILTV

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: HLA-A, HLAA expression_system_strain: pLysS expression_system_vector_type: plasmid expression_system_plasmid: pET

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: B2M, CDABP0092, HDCMA22P expression_system_vector_type: Plasmid expression_system_plasmid: pET

mol_id	organism_scientific	organism_common
3	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Celie, P.H.N., Rodenko, B., Ovaa, H.

Keywords :

Antigen Presentation, Major histocompatibility complex, HLA-A2 Antigen, Altered peptide ligand, immune system

Exp. method :

X-RAY DIFFRACTION ( 1.6500 Å )

Citation :

Altered Peptide Ligands Revisited: Vaccine Design through Chemically Modified HLA-A2-Restricted T Cell Epitopes.

Hoppes, R.,Oostvogels, R.,Luimstra, J.J. et al.
(2014) J Immunol. 193 : 4803 - 4813

PDB ID: 4WJ5