Brand  (β version)

PDB ID: 4WAS

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Ligands
Code Name Style Show Link
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
COO Crotonyl coenzyme a PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 4WAS   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : STRUCTURE OF THE ETR1P/NADP/CROTONYL-COA COMPLEX
Release Data : 2015-03-18
Compound :
mol_id molecule chains synonym
1 Enoyl-[acyl-carrier-protein] reductase [NADPH, B-specific] 1, mitochondrial A,B,C Trans-2-enoyl-CoA reductase 1
ec: 1.3.1.10,1.3.1.38
Source :
mol_id organism_scientific organism_common expression_system
1 Candida tropicalis  (taxid:5482) Yeast Escherichia coli BL21(DE3)  (taxid:469008)
gene: ETR1
expression_system_plasmid: pt7-7
Authors : Quade, N., Voegeli, B., Rosenthal, R., Capitani, G., Erb, T.J.
Keywords : MITOCHONDRIAL FATTY ACID SYNTHESIS, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.700 Å )
Citation :

The use of ene adducts to study and engineer enoyl-thioester reductases.

Rosenthal, R.G.,Vogeli, B.,Quade, N.  et al.
(2015)  Nat.Chem.Biol.  11 : 398 - 400

PubMed: 25867044
DOI: 10.1038/nchembio.1794

Reaction

Chain : A, B, C
UniProt : Q8WZM3 (ETR1_CANTR)
Reaction: EC: Evidence:
Physiological Direction:
a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH 1.3.1.104 PubMed:12890667
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(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (4E)-hexenoyl-CoA + NADP(+) - PubMed:11509667
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(2E)-hexenoyl-CoA + H(+) + NADPH = hexanoyl-CoA + NADP(+) - PubMed:11509667
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