Brand  (β version)

PDB ID: 4V37

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Ligands
Code Name Style Show Link
NAD Nicotinamide-adenine-dinucleotide PoSSuM
0D8 3-aminopropan-1-ol PoSSuM
FMT Formic acid PoSSuM
PG4 Tetraethylene glycol PoSSuM
K Potassium ion PoSSuM
AE3 2-(2-ethoxyethoxy)ethanol PoSSuM
Non-standard Residues
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Structure summary

Code : 4V37   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of betaine aldehyde dehydrogenase from spinach showing a thiohemiacetal with 3-aminopropionaldehyde
Release Data : 2016-01-20
Compound :
mol_id molecule chains
1 BETAINE ALDEHYDE DEHYDROGENASE, CHLOROPLASTIC A,B,C,D
ec: 1.2.1.8
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 SPINACIA OLERACEA  (taxid:3562) SPINACH ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
expression_system_vector_type: PLASMID
expression_system_vector: PET-28B
Authors : Zarate-Romero, A., Munoz-Clares, R.A.
Keywords : OXIDOREDUCTASE, BETAINE ALDEHYDE DEHYDROGENASE, ALDH10
Exp. method : X-RAY DIFFRACTION ( 2.100 Å )
Citation :

Identification of a Stable Thiohemiacetal Involving a Conserved Cysteine in the Substrate Inactivation of S. Oleracea Betaine Aldehyde Dehydrogenase

Zarate-Romero, A.,Mujica-Jimenez, C.,Murillo-Melo, D.S.  et al.
To be Published 

Reaction

Chain : A, B, C, D
UniProt : P17202 (BADH_SPIOL)
Reaction: EC: Evidence:
Physiological Direction:
4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH 1.2.1.19 PubMed:22345508
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3-aminopropanal + H2O + NAD(+) = beta-alanine + 2 H(+) + NADH - PubMed:22345508
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4-(trimethylamino)butanal + H2O + NAD(+) = 4- (trimethylamino)butanoate + 2 H(+) + NADH 1.2.1.47 PubMed:22345508
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betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH 1.2.1.8 PubMed:22345508
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