Brand  (β version)

PDB ID: 4UMU

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Ligands
Code Name Style Show Link
0V0 (2-ethoxy-4-{[3-(isoquinolin-7-yl)prop-2-yn-1-yl]oxy}phenyl)methanaminium PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4UMU   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of MELK in complex with inhibitors
Release Data : 2014-10-22
Compound :
mol_id molecule chains synonym
1 MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE A HMELK, PROTEIN KINASE EG3, PEG3 KINASE, PROTEIN KINASE PK38 , HPK38, TYROSINE-PROTEIN KINASE MELK
ec: 2.7.11.1, 2.7.10.2
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
other_details: IMAGE CLONE
Authors : Johnson, C.N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D.C., Sharff, A., Sommen, F., Wu, T., Linders, J.T.M.
Keywords : TRANSFERASE, FRAGMENT BASED DRUG DESIGN, KINASE
Exp. method : X-RAY DIFFRACTION ( 2.02 Å )
Citation :

Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.

Johnson, C.N.,Adelinet, C.,Berdini, V.  et al.
(2015)  Acs Med.Chem.Lett.  6 : 31

PubMed: 25589926
DOI: 10.1021/ML5001273

Reaction

Chain : A
UniProt : Q14680 (MELK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10027, PubMed:16216881
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ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:16216881
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:16216881
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