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Ligands
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0V5 (2r)-2-(phosphonooxy)propanoic acid
MN Manganese (II) ion
PO4 Phosphate ion
Non-standard Residues
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Glycosylation
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Code : 4UMB   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water
Release Data : 2014-10-08
Compound :
mol_id molecule chains synonym
1 PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE A,B,C,D 3-DEOXY-D-ARABINO-HEPTULOSONATE 7-PHOSPHATE SYNTHASE, DAHP SYNTHASE, PHOSPHO-2-KETO-3-DEOXYHEPTONATE ALDOLASE
ec: 2.5.1.54
Source :
mol_id organism_scientific expression_system
1 NEISSERIA MENINGITIDIS  (taxid:122586) ESCHERICHIA COLI  (taxid:469008)
strain: MC58
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PT7/7
Authors : Heyes, L.C., Reichau, S., Cross, P.J., Parker, E.J.
Keywords : TRANSFERASE, DAH7PS, DAHPS, AROMATIC AMINO ACIDS, SHIKIMATE PATHWAY, OXOCARBENIUM ION, MENINGITIS
Exp. method : X-RAY DIFFRACTION ( 2.17 Å )
Citation :

Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water.

Heyes, L.C.,Reichau, S.,Cross, P.J.  et al.
(2014)  Bioorg.Chem.  57 : 242

PubMed: 25245459
DOI: 10.1016/J.BIOORG.2014.08.003

Chain : A, B, C, D
UniProt : Q9K169 (Q9K169_NEIMB)
Reaction: EC: Evidence:
Physiological Direction:
D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7- phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate 2.5.1.54 ARBA:ARBA00001370, PIRNR:PIRNR001361
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