Brand  (β version)

PDB ID: 4UIA

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Ligands
Code Name Style Show Link
FH9 (2s)-6-azanyl-2-[[(2r)-3-cyclohexyl-1-(3-methylbutylamino)-1-oxidanylidene-propan-2-yl]carbamoylamino]hexanoic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4UIA   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of 3a in complex with tafCPB
Release Data : 2015-06-03
Compound :
mol_id molecule chains synonym
1 CARBOXYPEPTIDASE B A TAFCPB
ec: 3.4.17.2, 3.4.17.20
fragment: CATALYTIC DOMAIN, RESIDUES 111-416
mutation: YES
other_details: CONTAINS CATALYTIC ZINC ION.
Source :
mol_id organism_scientific organism_common expression_system
1 SUS SCROFA  (taxid:9823) PIG PICHIA PASTORIS  (taxid:644223)
expression_system_strain: GS115
Authors : Halland, N., Broenstrup, M., Czech, J., Czechtizky, W., Evers, A., Follmann, M., Kohlmann, M., Schiell, M., Kurz, M., Schreuder, H.A., Kallus, C.
Keywords : HYDROLASE, TAFI, CARBOXYPEPTIDASE, THROMBOSIS, FIBRINOLYSIS, DRUG DISCOVERY
Exp. method : X-RAY DIFFRACTION ( 2.18 Å )
Citation :

Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (Tafia) from Natural Product Anabaenopeptin.

Halland, N.,Bronstrup, M.,Czech, J.  et al.
(2015)  J.Med.Chem.  58 : 4839

PubMed: 25990761
DOI: 10.1021/JM501840B

Reaction

Chain : A
UniProt : P09955 (CBPB1_PIG)
Reaction: EC: Evidence:
Physiological Direction:
Preferential release of a C-terminal lysine or arginine amino acid. 3.4.17.2 UniProtKB:P00732
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