Het-PDB Navi2 (PDB: 4U93)

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Ligands
Code	Name		Style	Show	Link
990	(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-D]pyrimidin-5(6h)-one				PoSSuM

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Download interaction data: 4U93

Code :

4U93 PDBj RCSB PDB PDBe

Header :

CHAPERONE

Title :

Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990

Release Data :

2014-11-19

Compound :

mol_id	molecule	chains	synonym
1	Heat shock protein HSP 90-alpha	A	Heat shock 86 kDa,HSP86,Lipopolysaccharide-associated protein 2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38
	fragment: ATP-binding domain, UNP residues 1-236

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia Coli (taxid:562)

Authors :

Bellamacina, C.R., Shafer, C.M., Bussiere, D.

Keywords :

ATP-binding domain, CHAPERONE

Exp. method :

X-RAY DIFFRACTION ( 1.5500 Å )

Citation :

Design, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990.

McBride, C.M.,Levine, B.,Xia, Y. et al.
(2014) J.Med.Chem. 57 : 9124 - 9129

Chain :

UniProt :

P07900 (HS90A_HUMAN)

PDB ID: 4U93