Het-PDB Navi2 (PDB: 4U14)

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Ligands
Code	Name		Style	Show	Link
0HK	(1r,2r,4s,5s,7s)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane				PoSSuM

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Download interaction data: 4U14

Code :

4U14 PDBj RCSB PDB PDBe

Header :

MEMBRANE PROTEIN

Title :

Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)

Release Data :

2014-11-26

Compound :

mol_id	molecule	chains	synonym
1	Muscarinic acetylcholine receptor M3,Endolysin,Muscarinic acetylcholine receptor M3	A	Lysis protein,Lysozyme,Muramidase
	ec: 3.2.1.17 fragment: UNP P08483 residues 57-259, 482-563, P00720 residues 1-161

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Rat	Spodoptera frugiperda (taxid:7108)
	gene: Chrm3, Chrm-3

Authors :

Thorsen, T.S., Matt, R.A., Weis, W.I., Kobilka, B.K.

Keywords :

alpha helix, G protein-coupled receptors (GPCRs), membrane protein, T4 lysozyme, fusion protein, chimera protein

Exp. method :

X-RAY DIFFRACTION ( 3.57 Å )

Citation :

Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis.

Thorsen, T.S.,Matt, R.,Weis, W.I. et al.
(2014) Structure 22 : 1657 - 1664

Chain :

UniProt :

P00720 (ENLYS_BPT4)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.	3.2.1.17	HAMAP-Rule:MF_04110, PubMed:4865643
	-	HAMAP-Rule:MF_04110, PubMed:4865643

PDB ID: 4U14