Brand  (β version)

PDB ID: 4TVJ

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Ligands
Code Name Style Show Link
09L 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2h)-one PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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Structure summary

Code : 4TVJ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : HUMAN ARTD2 (PARP2) - CATALYTIC DOMAIN IN COMPLEX WITH OLAPARIB
Release Data : 2015-07-08
Compound :
mol_id molecule chains synonym
1 Poly [ADP-ribose] polymerase 2 A,B hPARP-2,ADP-ribosyltransferase diphtheria toxin-like 2,ARTD2,NAD(+) ADP-ribosyltransferase 2,ADPRT-2,Poly[ADP-ribose] synthase 2,pADPRT-2
ec: 2.4.2.30
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: PARP2, ADPRT2, ADPRTL2
expression_system_strain: R3 PRARE
expression_system_vector_type: PLASMID
expression_system_plasmid: PNIC28-BSA4
Authors : Karlberg, T., Thorsell, A.G., Ekblad, T., Pinto, A.F., Schuler, H.
Keywords : Poly(ADP-Ribose) transferase, Inhibitor, ADP-Ribosylation, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.

Thorsell, A.G.,Ekblad, T.,Karlberg, T.  et al.
(2017)  J. Med. Chem.  60 : 1262 - 1271

PubMed: 28001384
DOI: 10.1021/acs.jmedchem.6b00990

Reaction

Chain : A, B
UniProt : Q9UGN5 (PARP2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H(+). 2.4.2.30 PubMed:25043379, PubMed:30104678, PubMed:30321391, PubMed:32939087
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L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D- ribosyl)-L-seryl-[protein] - PubMed:32028527, PubMed:32939087, PubMed:34108479, PubMed:28190768
left-to-right PubMed:32028527, PubMed:32939087, PubMed:34108479, PubMed:28190768
L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide - PubMed:25043379
left-to-right
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide - PubMed:25043379
left-to-right