Brand  (β version)

PDB ID: 4TLM

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Ligands
Code Name Style Show Link
1AC 1-aminocyclopropanecarboxylic acid PoSSuM
JEG Trans-1-aminocyclobutane-1,3-dicarboxylic acid PoSSuM
QEM 4-[(1r,2s)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol PoSSuM
Non-standard Residues
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Glycosylation
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NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 4TLM   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Crystal structure of GluN1/GluN2B NMDA receptor, structure 2
Release Data : 2014-07-02
Compound :
mol_id molecule chains synonym
1 receptor subunit GluN1 A,C N-methyl-D-aspartate receptor subunit NR1-8a
fragment: UNP residues 22-836
mutation: C22A, K51F, K52F, N300Q, N350Q, N368D, N440D, N469D, K493A, K494A, E495A, G610R, I617L, D656R, N769E, Del(K588-E595), Replacement of 845-853 with SRAEAKRMK
mol_id molecule chains synonym
2 receptor subunit GluN2B B,D Ionotropic glutamate receptor subunit NR2B
fragment: UNP residues 20-839
mutation: M20S, G21R, C22A, A64E, N69Q, K216C, N343D, T490V, C585A, E654R, E655R, V615L, Del(K382-V385), Del(R584-G593), Replacement of 854-864 with YKSRAEAKRMK
Source :
mol_id organism_scientific organism_common expression_system
1 Xenopus laevis  (taxid:8355) African clawed frog Homo sapiens  (taxid:9606)
expression_system_common: Human
mol_id organism_scientific organism_common expression_system
2 Xenopus laevis  (taxid:8355) African clawed frog Homo sapiens  (taxid:9606)
gene: NR2B
expression_system_common: Human
Authors : Gouaux, E., Lee, C.-H., Lu, W.
Keywords : neurotransmitter receptor, NMDA receptor, GluN1/GluN2B, membrane protein, ion channel, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 3.770 Å )
Citation :

NMDA receptor structures reveal subunit arrangement and pore architecture.

Lee, C.H.,Lu, W.,Michel, J.C.  et al.
(2014)  Nature  511 : 191 - 197

PubMed: 25008524
DOI: 10.1038/nature13548

Reaction

Chain : A, C
UniProt : C0KD18 (NMDZ1_XENLA)
Reaction: EC: Evidence:
Physiological Direction:
Ca(2+)(in) = Ca(2+)(out) - PubMed:16214956, PubMed:19524674
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Na(+)(in) = Na(+)(out) - UniProtKB:Q05586
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K(+)(in) = K(+)(out) - UniProtKB:P35438
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Chain : B, D
UniProt : A7XY94 (NMDE2_XENLA)
Reaction: EC: Evidence:
Physiological Direction:
Ca(2+)(in) = Ca(2+)(out) - PubMed:18177891, PubMed:25008524, PubMed:28232581
-
Na(+)(in) = Na(+)(out) - UniProtKB:Q13224
-
K(+)(in) = K(+)(out) - UniProtKB:P35438
-