Brand  (β version)

PDB ID: 4THN

Hetero Atom Contents

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
AIB Alpha-aminoisobutyric acid
ALC 2-amino-3-cyclohexyl-propionic acid
BAL Beta-alanine
CHG Cyclohexyl-glycine
DAL D-alanine
DGL D-glutamic acid
HMF 2-amino-4-phenyl-butyric acid
NAL Beta-(2-naphthyl)-alanine
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 4THN   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : THE CRYSTAL STRUCTURE OF ALPHA-THROMBIN-HIRUNORM IV COMPLEX REVEALS A NOVEL SPECIFICITY SITE RECOGNITION MODE.
Release Data : 1999-06-15
Compound :
mol_id molecule chains
1 ALPHA-THROMBIN L
ec: 3.4.21.5
mol_id molecule chains
2 ALPHA-THROMBIN H
ec: 3.4.21.5
mol_id molecule chains
3 HIRUNORM IV I
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
organ: SEED
tissue: PLASMA
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
organ: SEED
tissue: PLASMA
mol_id organism_scientific
3
other_details: CHEMICAL SYNTHESIS
Authors : Lombardi, A., De Simone, G., Nastri, F., Galdiero, S., Della Morte, R., Staiano, N., Pedone, C., Bolognesi, M., Pavone, V.
Keywords : COMPLEX (SERINE PROTEASE-INHIBITOR), THROMBIN SYNTHETIC INHIBITORS, ANTITHROMBOTICS, HIRUDIN-LIKE BINDING MODE, HIRUNORMS, THROMBIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

The crystal structure of alpha-thrombin-hirunorm IV complex reveals a novel specificity site recognition mode.

Lombardi, A.,De Simone, G.,Nastri, F.  et al.
(1999)  Protein Sci.  8 : 91 - 95

PubMed: 10210187

The Structure of a Complex of Recombinant Hirudin and Human Alpha-Thrombin

Rydel, T.J.,Ravichandran, K.G.,Tulinsky, A.  et al.
(1990)  Science  249 : 277

Hirunorms are True Hirudin Mimetics. The Crystal Structure of Human Alpha-Thrombin-Hirunorm V Complex

De Simone, G.,Lombardi, A.,Galdiero, S.  et al.
(1998)  Protein Sci.  7 : 243

Rational Design of True Hirudin Mimetics: Synthesis and Characterization of Multisite-Directed Alpha-Thrombin Inhibitors

Lombardi, A.,Nastri, F.,Della Morte, R.  et al.
(1996)  J.Med.Chem.  39 : 2008

Refined Structure of the Hirudin-Thrombin Complex

Rydel, T.J.,Tulinsky, A.,Bode, W.  et al.
(1991)  J.Mol.Biol.  221 : 583

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
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