Brand  (β version)

PDB ID: 4S2T

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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01B (2s,3r)-3-amino-2-hydroxy-4-phenylbutanoic acid
Glycosylation
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NH2 Amino group

Structure summary

Code : 4S2T   PDBj   RCSB PDB   PDBe
Header : Hydrolase/hydrolase inhibitor
Title : Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: a cytosolic enzyme with a di-nuclear active site
Release Data : 2015-04-22
Compound :
mol_id molecule chains
1 Protein APP-1 P,Q
mol_id molecule chains
2 apstatin A,B
Source :
mol_id organism_scientific organism_common expression_system
1 Caenorhabditis elegans  (taxid:6239) Roundworm Escherichia coli  (taxid:469008)
gene: app-1, CELE_W03G9.4, W03G9.4
expression_system_strain: BL21-Codon-Plus (DE3)-RIL
expression_system_vector_type: plasmid
expression_system_plasmid: pET19b
mol_id organism_scientific
2
synthetic: yes
Authors : Iyer, S., La-Borde, P., Payne, K.A.P., Parsons, M.R., Turner, A.J., Isaac, R.E., Acharya, K.R.
Keywords : pitta-bread fold, metalloprotease, zinc binding, Hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site.

Iyer, S.,La-Borde, P.J.,Payne, K.A.  et al.
(2015)  FEBS Open Bio  5 : 292 - 302

PubMed: 25905034
DOI: 10.1016/j.fob.2015.03.013

Reaction

Chain : P, Q
UniProt : O44750 (XPP_CAEEL)
Reaction: EC: Evidence:
Physiological Direction:
Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. 3.4.11.9 PubMed:11606206
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