Brand  (β version)

PDB ID: 4RYD

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Ligands
Code Name Style Show Link
FMT Formic acid PoSSuM
CA Calcium ion PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
Code Name Show
TBG 3-methyl-L-valine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
2UE 1-[4-(2-oxoethyl)benzyl]guanidine
00S 4-(aminomethyl)benzenecarboximidamide

Structure summary

Code : 4RYD   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase Inhibitor
Title : X-ray structure of human furin in complex with the competitive inhibitor para-guanidinomethyl-Phac-R-Tle-R-Amba
Release Data : 2015-05-27
Compound :
mol_id molecule chains synonym
1 Furin A,B,C,D,E,F Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, PACE
ec: 3.4.21.75
fragment: UNP residues 108-574
mol_id molecule chains
2 para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine H,I,J,K,L,N
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: FUR, FURIN, PACE, PCSK3
expression_system_cell_line: HEK293S
expression_system_vector_type: PLASMID
expression_system_plasmid: pHLsec
mol_id organism_scientific
2
synthetic: yes
Authors : Dahms, S.O., Than, M.E.
Keywords : competitive inhibitor, pro-protein convertase, serine protease, Hydrolase-Hydrolase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Novel Furin Inhibitors with Potent Anti-infectious Activity.

Hardes, K.,Becker, G.L.,Lu, Y.  et al.
(2015)  Chemmedchem  10 : 1218 - 1231

PubMed: 25974265
DOI: 10.1002/cmdc.201500103

Reaction

Chain : A, B, C, D, E, F
UniProt : P09958 (FURIN_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors. 3.4.21.75 PubMed:11799113, PubMed:1438214, PubMed:1629222, PubMed:1644824, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:31091448, PubMed:32362314, PubMed:32703818, PubMed:7592877, PubMed:7690548, PubMed:7737999, PubMed:8253774, PubMed:9130696
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