Het-PDB Navi2 (PDB: 4RUP)

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Ligands
Code	Name		Style	Show	Link
H97	(1r,3r,7e,17beta)-17-[(1r)-6,6,6-trifluoro-5-hydroxy-1-(4-hydroxy-4-methylpentyl)-5-(trifluoromethyl)hex-3-yn-1-yl]-9,1 0-secoestra-5,7-diene-1,3-diol				PoSSuM

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Download interaction data: 4RUP

Code :

4RUP PDBj RCSB PDB PDBe

Header :

Transcription Factor

Title :

Crystal structure of zVDR L337H mutant-Gemini72 complex

Release Data :

2015-10-07

Compound :

mol_id	molecule	chains	synonym
1	Vitamin D3 receptor A	A	VDR-A, 1,25-dihydroxyvitamin D3 receptor A, Nuclear receptor subfamily 1 group I member 1-A
	fragment: ligand binding domain, UNP residues 156-453 mutation: L337H

mol_id	molecule	chains	synonym
2	Nuclear receptor coactivator 1	B	NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1
	fragment: UNP residues 686-700

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Danio rerio (taxid:7955)	Leopard danio,zebra danio,zebra fish	Escherichia coli (taxid:469008)
	gene: vdra, nr1i1a, vdr expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET28

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes other_details: This sequence occurs naturally in human

Authors :

Huet, T., Moras, D., Rochel, N.

Keywords :

alpha helical sandwich, transcription factor, retinoid X receptor, ligand, DNA, phosphorylation, nucleus

Exp. method :

X-RAY DIFFRACTION ( 2.750 Å )

Citation :

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.

Huet, T.,Laverny, G.,Ciesielski, F. et al.
(2015) Cell Rep 10 : 516 - 526

PDB ID: 4RUP