Brand  (β version)

PDB ID: 4RKM

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Ligands
Code Name Style Show Link
CU1 Copper (I) ion PoSSuM
SX Sulfur oxide PoSSuM
BU3 (R,R)-2,3-butanediol PoSSuM
ACT Acetate ion PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
SO2 Sulfur dioxide PoSSuM
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Structure summary

Code : 4RKM   PDBj   RCSB PDB   PDBe
Header : UNKNOWN FUNCTION
Title : Wolinella succinogenes octaheme sulfite reductase MccA, form I
Release Data : 2015-02-04
Compound :
mol_id molecule chains
1 MccA A,B,C,D,E,F,H,I,J,K,L,G
Source :
mol_id organism_scientific expression_system
1 Wolinella succinogenes DSM 1740  (taxid:273121) Wolinella succinogenes  (taxid:844)
strain: ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W
gene: mccA, WS0379
expression_system_vector_type: homologous recombination
Authors : Hermann, B., Kern, M., La Pietra, L., Simon, J., Einsle, O.
Keywords : multiheme cytochrome c, sulfite reductase, periplasmic, UNKNOWN FUNCTION
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

The octahaem MccA is a haem c-copper sulfite reductase.

Hermann, B.,Kern, M.,La Pietra, L.  et al.
(2015)  Nature  520 : 706 - 709

PubMed: 25642962
DOI: 10.1038/nature14109

Reaction

Chain : A, B, C, D, E, F, H, I, J, K, L, G
UniProt : Q7MSJ8 (MCCA_WOLSU)
Reaction: EC: Evidence:
Physiological Direction:
[protein]-disulfide + hydrogen sulfide + 2 A + 3 H2O = [protein]-dithiol + sulfite + 2 AH2 + H(+) - PubMed:22040142, PubMed:25642962
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Cofactor: Evidence: Note:
Cu(+) ECO:0000269 | PubMed:25642962
Exposure to oxygen reduces copper binding and leads to the formation of a disulfide bond between the two Cys residues that bind the copper ion.
heme c ECO:0000269 | PubMed:17501927
ECO:0000269 | PubMed:22040142
ECO:0000269 | PubMed:25642962
Binds 8 heme c groups covalently per monomer.