Brand  (β version)

PDB ID: 4RBS

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
0RV (2s)-2-[(1s,2r)-1-carboxy-2-hydroxypropyl]-4-{[(3s,5s)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-3-methyl-2h-pyrro le-5-carboxylic acid PoSSuM
ACY Acetic acid PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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Structure summary

Code : 4RBS   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem
Release Data : 2014-11-26
Compound :
mol_id molecule chains synonym
1 Beta-lactamase NDM-1 A,B NDM-1, Metallo-beta-lactamase NDM-1
ec: 3.5.2.6
fragment: Residues 31-270
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli  (taxid:469008)
gene: blaNDM-1
expression_system_strain: BL21 DE3 gold
expression_system_vector_type: plasmid
expression_system_plasmid: pMCSG7
Authors : Kim, Y., Tesar, C., Jedrzejczak, R., Babnigg, G., Sacchettini, J., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)
Keywords : Structural Genomics, PSI-Biology, Midwest Center for Structural Genomics, MCSG, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors, MTBI, alpha-beta-beta-alpha sandwich, hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.405 Å )
Citation :

Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem

Kim, Y.,Tesar, C.,Jedrzejczak, R.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : C7C422 (BLAN1_KLEPN)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PubMed:19770275
-
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:22713171
ECO:0000269 | PubMed:25815530
Binds 2 Zn(2+) ions per subunit.