Brand  (β version)

color scheme of protein:

chain: Hide other chain(s)

Ligands
Code Name Link
K Potassium ion
NA Sodium ion
SR Strontium ion
Modified Residues
Code Name Link
0A L-adenosine-5'-monophosphate
0C L-cytidine-5'-monophosphate
0G L-guanosine-5'-monophosphate
0U L-uridine-5'-monophosphate
0U1 2'-methylselenyl-2'-deoxy-L-uridine-5'-monophosphate
Code : 4R8I   PDBj   RCSB PDB   PDBe
Header : Cytokine/RNA
Title : High Resolution Structure of a Mirror-Image RNA Oligonucleotide Aptamer in Complex with the Chemokine CCL2
Release Data : 2015-04-29
Compound :
mol_id molecule chains synonym
1 C-C motif chemokine 2 A HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2
mol_id molecule chains
2 Mirror-Image RNA Oligonucleotide Aptamer NOXE36 B
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CCL2, MCP1, SCYA2
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
other_details: The NOX-E36 L-oligonucleotides with the sequence 5'-GCACGUCCCUCACCGGUGCAAGUGAAGCCGUGGCUCUGCG-3' were synthesized using standard phosphoramidite chemistry at NOXXON Pharma AG (Berlin, Germany)
Authors : Oberthuer, D., Achenbach, J., Gabdulkhakov, A., Falke, S., Buchner, K., Maasch, C., Rehders, D., Klussmann, S., Betzel, C.
Keywords : Aptamer Spiegelmer L-oligonucleotide, Cytokine-RNA complex
Exp. method : X-RAY DIFFRACTION ( 2.05 Å )
Citation :

Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2.

Oberthur, D.,Achenbach, J.,Gabdulkhakov, A.  et al.
(2015)  Nat Commun  6 : 6923 - 6923

PubMed: 25901662
DOI: 10.1038/ncomms7923

Chain : A
UniProt : P13500 (CCL2_HUMAN)
Reaction : -