Brand  (β version)

PDB ID: 4R7U

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Ligands
Code Name Style Show Link
FFQ [(1r)-1-hydroxypropyl]phosphonic acid PoSSuM
NA Sodium ion PoSSuM
PG4 Tetraethylene glycol PoSSuM
UD1 Uridine-diphosphate-N-acetylglucosamine PoSSuM
Non-standard Residues
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Structure summary

Code : 4R7U   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/ANTIBIOTIC
Title : Structure of UDP-N-acetylglucosamine 1-carboxyvinyltransferase from Vibrio cholerae in complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin
Release Data : 2014-09-24
Compound :
mol_id molecule chains synonym
1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase A,B,C,D Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT
ec: 2.5.1.7
Source :
mol_id organism_scientific expression_system
1 Vibrio cholerae O1 biovar El Tor str. N16961  (taxid:243277) Escherichia coli  (taxid:469008)
strain: N16961
gene: murA, VC_2514
expression_system_strain: BL21(DE3)
Authors : Nocek, B., Maltseva, N., Anderson, W., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Keywords : MURA, FOSFOMYCIN, PEPTIDOGLYCAN, AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM, PEPTIDOGLYCAN BIOSYNTHESIS, Structural Genomics, NIAID, National Institute of Allergy and Infectious Diseases, Center for Structural Genomics of Infectious Diseases, CSGID, UDP-N-acetylglucosamine 1-carboxyvinyltransferase, TRANSFERASE-ANTIBIOTIC complex
Exp. method : X-RAY DIFFRACTION ( 2.45 Å )
Citation :

Structure of UDP-N-acetylglucosamine 1-carboxyvinyltransferase from Vibrio cholerae in complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin

Nocek, B.,Maltseva, N.,Anderson, W.  et al.
To be Published 

Reaction

Chain : A, B, C, D
UniProt : Q9KP62 (MURA_VIBCH)
Reaction: EC: Evidence:
Physiological Direction:
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine 2.5.1.7 HAMAP-Rule:MF_00111
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