Het-PDB Navi2 (PDB: 4R5S)

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Ligands
Code	Name		Style	Show	Link
FI3	N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide				PoSSuM

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Download interaction data: 4R5S

Code :

4R5S PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of EGFR 696-1022 L858R in complex with FIIN-3

Release Data :

2014-11-12

Compound :

mol_id	molecule	chains	synonym
1	Epidermal growth factor receptor	A	Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
	ec: 2.7.10.1 fragment: UNP RESIDUES 696-1022 mutation: L858R

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: EGFR, ERBB, ERBB1, HER1 expression_system_common: Fall armyworm expression_system_vector_type: Baculovirus

Authors :

Zhu, S.J., Yun, C.H.

Keywords :

EGFR, L858R, Kinase, FIIN-3, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 3.001 Å )

Citation :

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.

Tan, L.,Wang, J.,Tanizaki, J. et al.
(2014) Proc.Natl.Acad.Sci.USA 111 : E4869 - E4877

Chain :

UniProt :

P00533 (EGFR_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:15374980, PubMed:17349580, PubMed:18046415, PubMed:18227510, PubMed:19560417, PubMed:19563760
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PDB ID: 4R5S