Het-PDB Navi2 (PDB: 4QZS)

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Ligands
Code	Name	Link
CL	Chloride ion	PoSSuM
EDO	1,2-ethanediol	PoSSuM
JQ1	(6s)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium	PoSSuM

Non-standard Residues
Code	Name	Show
YOF	3-fluorotyrosine

Glycosylation
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Download interaction data: 4QZS

Code :

4QZS PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Crystal structure of the first bromodomain of human 3-fluoro tyrosine-labeled brd4 in complex with jq1

Release Data :

2014-10-29

Compound :

mol_id	molecule	chains	synonym
1	Bromodomain-containing protein 4	A	Protein HUNK1
	fragment: Bromo 1 domain residues 44-168

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: BRD4, HUNK1 expression_system_strain: DL39(DE3)-pRARE expression_system_vector_type: PLASMID expression_system_plasmid: PNIC28-BSA4

Authors :

Ember, S.W., Schonbrunn, E.

Keywords :

CAP, MCAP, PROTEIN BINDING-INHIBITOR COMPLEX, MITOTIC CHROMOSOME ASSOCIATED PROTEIN, CELL CYCLE, INHIBITOR, TRANSCRIPTION

Exp. method :

X-RAY DIFFRACTION ( 1.450 Å )

Citation :

Fluorinated aromatic amino acids are sensitive (19)f NMR probes for bromodomain-ligand interactions.

Mishra, N.K.,Urick, A.K.,Ember, S.W. et al.
(2014) Acs Chem.Biol. 9 : 2755 - 2760

PDB ID: 4QZS