Brand  (β version)

PDB ID: 4QZ1

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Ligands
Code Name Style Show Link
04C 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol PoSSuM
CL Chloride ion PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 4QZ1   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : yCP beta5-M45T mutant in complex with the epoxyketone inhibitor ONX 0914
Release Data : 2015-02-04
Compound :
mol_id molecule chains
1 Proteasome subunit alpha type-2 A,O
ec: 3.4.25.1
mutation: M45I
mol_id molecule chains
2 Proteasome subunit alpha type-3 B,P
ec: 3.4.25.1
mol_id molecule chains
3 Proteasome subunit alpha type-4 C,Q
ec: 3.4.25.1
mol_id molecule chains
4 Proteasome subunit alpha type-5 D,R
ec: 3.4.25.1
mol_id molecule chains
5 Proteasome subunit alpha type-6 E,S
ec: 3.4.25.1
mol_id molecule chains
6 Probable proteasome subunit alpha type-7 F,T
ec: 3.4.25.1
mol_id molecule chains
7 Proteasome subunit alpha type-1 G,U
ec: 3.4.25.1
mol_id molecule chains
8 Proteasome subunit beta type-2 H,V
ec: 3.4.25.1
mol_id molecule chains
9 Proteasome subunit beta type-3 I,W
ec: 3.4.25.1
mol_id molecule chains
10 Proteasome subunit beta type-4 J,X
ec: 3.4.25.1
mol_id molecule chains
11 Proteasome subunit beta type-5 K,Y
ec: 3.4.25.1
mol_id molecule chains
12 Proteasome subunit beta type-6 L,Z
ec: 3.4.25.1
mol_id molecule chains
13 Proteasome subunit beta type-7 M,a
ec: 3.4.25.1
mol_id molecule chains
14 Proteasome subunit beta type-1 N,b
ec: 3.4.25.1
Source :
mol_id organism_scientific organism_common
1 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
2 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
3 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
4 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
5 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
6 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
7 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
8 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
9 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
10 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common expression_system
11 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast SACCHAROMYCES CEREVISIAE  (taxid:4932)
strain: ATCC 204508 / S288c
gene: PRE2, DOA3, PRG1, YPR103W, P8283.10
expression_system_strain: 4932
mol_id organism_scientific organism_common
12 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
13 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
14 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
Authors : Huber, E.M., Heinemeyer, W., Groll, M.
Keywords : Cancer, Proteasome, Bortezomib, Drug Resistance, Binding Analysis, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914.

Huber, E.M.,Heinemeyer, W.,Groll, M.
(2015)  Structure  23 : 407 - 417

PubMed: 25599643
DOI: 10.1016/j.str.2014.11.019

Reaction

Chain : A, O
UniProt : P23639 (PSA2_YEAST)
Reaction : -
Chain : B, P
UniProt : P23638 (PSA3_YEAST)
Reaction : -
Chain : C, Q
UniProt : P40303 (PSA4_YEAST)
Reaction : -
Chain : D, R
UniProt : P32379 (PSA5_YEAST)
Reaction : -
Chain : E, S
UniProt : P40302 (PSA6_YEAST)
Reaction : -
Chain : F, T
UniProt : P21242 (PSA7_YEAST)
Reaction : -
Chain : G, U
UniProt : P21243 (PSA1_YEAST)
Reaction : -
Chain : H, V
UniProt : P25043 (PSB2_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 -
-
Chain : I, W
UniProt : P25451 (PSB3_YEAST)
Reaction : -
Chain : J, X
UniProt : P22141 (PSB4_YEAST)
Reaction : -
Chain : K, Y
UniProt : P30656 (PSB5_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 -
-
Chain : L, Z
UniProt : P23724 (PSB6_YEAST)
Reaction : -
Chain : M, a
UniProt : P30657 (PSB7_YEAST)
Reaction : -
Chain : N, b
UniProt : P38624 (PSB1_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 -
-