Brand  (β version)

PDB ID: 4QWX

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Ligands
Code Name Style Show Link
04C 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol PoSSuM
CL Chloride ion PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
MG Magnesium ion PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4QWX   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : yCP in complex with the epoxyketone inhibitor ONX 0914
Release Data : 2015-02-04
Compound :
mol_id molecule chains synonym
1 PROTEASOME SUBUNIT ALPHA TYPE-2 A,O MACROPAIN SUBUNIT Y7, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT Y7, PROTEASOME COMPONENT Y7, PROTEINASE YSCE SUBUNIT 7
ec: 3.4.25.1
mol_id molecule chains synonym
2 PROTEASOME SUBUNIT ALPHA TYPE-3 B,P MACROPAIN SUBUNIT Y13, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT Y13, PROTEASOME COMPONENT Y13, PROTEINASE YSCE SUBUNIT 13
ec: 3.4.25.1
mol_id molecule chains synonym
3 PROTEASOME SUBUNIT ALPHA TYPE-4 C,Q MACROPAIN SUBUNIT PRE6, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE6, PROTEASOME COMPONENT PRE6, PROTEINASE YSCE SUBUNIT PRE6
ec: 3.4.25.1
mol_id molecule chains synonym
4 PROTEASOME SUBUNIT ALPHA TYPE-5 D,R MACROPAIN SUBUNIT PUP2, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP2, PROTEASOME COMPONENT PUP2, PROTEINASE YSCE SUBUNIT PUP2
ec: 3.4.25.1
mol_id molecule chains synonym
5 PROTEASOME SUBUNIT ALPHA TYPE-6 E,S MACROPAIN SUBUNIT PRE5, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE5, PROTEASOME COMPONENT PRE5, PROTEINASE YSCE SUBUNIT PRE5
ec: 3.4.25.1
mol_id molecule chains synonym
6 PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 F,T MACROPAIN SUBUNIT C1, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C1, PROTEASOME COMPONENT C1, PROTEINASE YSCE SUBUNIT 1
ec: 3.4.25.1
mol_id molecule chains synonym
7 PROTEASOME SUBUNIT ALPHA TYPE-1 G,U MACROPAIN SUBUNIT C7-ALPHA, MULTICATALYTIC ENDOPEPTIDASE COMPLEX C7, PROTEASOME COMPONENT C7-ALPHA, PROTEASOME COMPONENT Y8, PROTEINASE YSCE SUBUNIT 7, SCL1 SUPPRESSOR PROTEIN
ec: 3.4.25.1
mol_id molecule chains synonym
8 PROTEASOME SUBUNIT BETA TYPE-2 H,V MACROPAIN SUBUNIT PUP1, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP1, PROTEASOME COMPONENT PUP1, PROTEINASE YSCE SUBUNIT PUP1
ec: 3.4.25.1
mol_id molecule chains synonym
9 PROTEASOME SUBUNIT BETA TYPE-3 I,W MACROPAIN SUBUNIT PUP3, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP3, PROTEASOME COMPONENT PUP3
ec: 3.4.25.1
mol_id molecule chains synonym
10 PROTEASOME SUBUNIT BETA TYPE-4 J,X MACROPAIN SUBUNIT C11, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C11, PROTEASOME COMPONENT C11, PROTEINASE YSCE SUBUNIT 11
ec: 3.4.25.1
mol_id molecule chains synonym
11 PROTEASOME SUBUNIT BETA TYPE-5 K,Y MACROPAIN SUBUNIT PRE2, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE2, PROTEASOME COMPONENT PRE2, PROTEINASE YSCE SUBUNIT PRE2
ec: 3.4.25.1
mol_id molecule chains synonym
12 PROTEASOME SUBUNIT BETA TYPE-6 L,Z MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C5, PROTEASOME COMPONENT C5
ec: 3.4.25.1
mol_id molecule chains synonym
13 PROTEASOME SUBUNIT BETA TYPE-7 M,a MACROPAIN SUBUNIT PRE4, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE4, PROTEASOME COMPONENT PRE4, PROTEINASE YSCE SUBUNIT PRE4
ec: 3.4.25.1
mol_id molecule chains synonym
14 PROTEASOME SUBUNIT BETA TYPE-1 N,b MACROPAIN SUBUNIT PRE3, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE3, PROTEASOME COMPONENT PRE3, PROTEINASE YSCE SUBUNIT PRE3
ec: 3.4.25.1
Source :
mol_id organism_scientific organism_common
1 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
2 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
3 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
4 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
5 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
6 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
7 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
8 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
9 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
10 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common expression_system
11 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast SACCHAROMYCES CEREVISIAE  (taxid:4932)
strain: ATCC 204508 / S288c
gene: PRE2, DOA3, PRG1, YPR103W, P8283.10
expression_system_strain: 4932
mol_id organism_scientific organism_common
12 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
13 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
14 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
Authors : Huber, E.M., Heinemeyer, W., Groll, M.
Keywords : Cancer, Proteasome, Bortezomib, Drug Resistance, Binding Analysis, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914.

Huber, E.M.,Heinemeyer, W.,Groll, M.
(2015)  Structure  23 : 407 - 417

PubMed: 25599643
DOI: 10.1016/j.str.2014.11.019

Reaction

Chain : A, O
UniProt : P23639 (PSA2_YEAST)
Reaction : -
Chain : B, P
UniProt : P23638 (PSA3_YEAST)
Reaction : -
Chain : C, Q
UniProt : P40303 (PSA4_YEAST)
Reaction : -
Chain : D, R
UniProt : P32379 (PSA5_YEAST)
Reaction : -
Chain : E, S
UniProt : P40302 (PSA6_YEAST)
Reaction : -
Chain : F, T
UniProt : P21242 (PSA7_YEAST)
Reaction : -
Chain : G, U
UniProt : P21243 (PSA1_YEAST)
Reaction : -
Chain : H, V
UniProt : P25043 (PSB2_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 -
-
Chain : I, W
UniProt : P25451 (PSB3_YEAST)
Reaction : -
Chain : J, X
UniProt : P22141 (PSB4_YEAST)
Reaction : -
Chain : K, Y
UniProt : P30656 (PSB5_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 -
-
Chain : L, Z
UniProt : P23724 (PSB6_YEAST)
Reaction : -
Chain : M, a
UniProt : P30657 (PSB7_YEAST)
Reaction : -
Chain : N, b
UniProt : P38624 (PSB1_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 -
-