Brand  (β version)

PDB ID: 4QWE

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
FTD [(2r,5s)-5-(4-amino-5-fluoro-2-oxo-3,6-dihydropyrimidin-1(2h)-yl)-1,3-oxathiolan-2-yl]methyl trihydrogen diphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4QWE   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/DNA
Title : TERNARY CRYSTAL STRUCTURES of A Y-FAMILY DNA POLYMERASE DPO4 FROM SULFOLOBUS SOLFATARICUS IN COMPLEX WITH DNA AND (-)FTC-DP
Release Data : 2014-08-27
Compound :
mol_id molecule chains synonym
1 DNA polymerase IV A Pol IV
ec: 2.7.7.7
mol_id molecule chains
2 DNA (5'-D(P*GP*GP*CP*TP*AP*CP*AP*GP*GP*AP*CP*TP*C)-3') C
other_details: GGCTACAGGACTC
mol_id molecule chains
3 DNA (5'-D(P*CP*AP*GP*GP*AP*GP*TP*CP*CP*TP*GP*TP*AP*GP*CP*C)-3') D
other_details: CAGGAGTCCTGTAGCC
Source :
mol_id organism_scientific expression_system
1 Sulfolobus solfataricus  (taxid:273057) Escherichia coli  (taxid:562)
strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2
gene: dbh, dpo4, SSO2448
expression_system_plasmid: pET21b
mol_id organism_scientific
2
synthetic: yes
other_details: RANDOM SEQUENCE, CHEMICALLY SYNTHESIZED
mol_id organism_scientific
3
synthetic: yes
other_details: RANDOM SEQUENCE, CHEMICALLY SYNTHESIZED
Authors : Gaur, V., Suo, Z.
Keywords : Y-FAMILY DNA POLYMERASE, TRANSFERASE-DNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Structural and kinetic insights into binding and incorporation of L-nucleotide analogs by a Y-family DNA polymerase.

Gaur, V.,Vyas, R.,Fowler, J.D.  et al.
(2014)  Nucleic Acids Res.  42 : 9984 - 9995

PubMed: 25104018
DOI: 10.1093/nar/gku709

Reaction

Chain : A
UniProt : Q97W02 (DPO4_SACS2)
Reaction: EC: Evidence:
Physiological Direction:
DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate 2.7.7.7 -
-
Cofactor: Evidence: Note:
Mg(2+) - Binds 2 magnesium ions per subunit.