PDB ID: 4QRC
Hetero Atom Contents
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Color scheme of protein:
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0LI | 3-(imidazo[1,2-B]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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Download interaction data: 4QRC
Structure summary
Code : | 4QRC PDBj RCSB PDB PDBe | ||||||||||||
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Header : | Transferase/transferase inhibitor | ||||||||||||
Title : | Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 4 in Complex with Ponatinib | ||||||||||||
Release Data : | 2014-10-29 | ||||||||||||
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Authors : | Huang, Z., Mohammadi, M. | ||||||||||||
Keywords : | Kinase Domain Fold, Cell Signaling, Phosphotransferase, Plasmamembrane, Transferase-transferase inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.901 Å ) | ||||||||||||
Citation : |
DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Huang, Z.,Tan, L.,Wang, H.
et al.
PubMed: 25317566 |
Reaction
Chain : | A | ||||||||
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UniProt : | P22455 (FGFR4_HUMAN) | ||||||||
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