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Ligands
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0LI 3-(imidazo[1,2-B]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide
SO4 Sulfate ion
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Code : 4QRC   PDBj   RCSB PDB   PDBe
Header : Transferase/transferase inhibitor
Title : Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 4 in Complex with Ponatinib
Release Data : 2014-10-29
Compound :
mol_id molecule chains synonym
1 Fibroblast growth factor receptor 4 A FGFR-4
ec: 2.7.10.1
fragment: Tyrosine Kinase Domain of FGF receptor 4
mutation: C477A, R664E
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: FGFR4, JTK2, TKF
Authors : Huang, Z., Mohammadi, M.
Keywords : Kinase Domain Fold, Cell Signaling, Phosphotransferase, Plasmamembrane, Transferase-transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.901 Å )
Citation :

DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.

Huang, Z.,Tan, L.,Wang, H.  et al.
(2015)  Acs Chem.Biol.  10 : 299 - 309

PubMed: 25317566
DOI: 10.1021/cb500674s

Chain : A
UniProt : P22455 (FGFR4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:11433297, PubMed:17311277, PubMed:18480409, PubMed:18670643
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