Het-PDB Navi2 (PDB: 4Q8O)

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Ligands
Code	Name	Link
CKR	6-amino-2-[(2-morpholin-4-ylethyl)amino]-3,7-dihydro-8h-imidazo[4,5-G]quinazolin-8-one	PoSSuM
GOL	Glycerol	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4Q8O

Code :

4Q8O PDBj RCSB PDB PDBe

Header :

Transferase/transferase inhibitor

Title :

tRNA-Guanine Transglycosylase (TGT) Mutant V262T in Complex with 6-Amino-2-{[2-(morpholin-4-yl)ethyl]amino}-1H,7H,8H-imidazo[4,5-G]quinazolin-8-one

Release Data :

2015-05-20

Compound :

mol_id	molecule	chains	synonym
1	Queuine tRNA-ribosyltransferase	A	Guanine insertion enzyme, tRNA-guanine transglycosylase
	ec: 2.4.2.29 mutation: V262T

Source :

mol_id	organism_scientific	expression_system
1	Zymomonas mobilis subsp. mobilis (taxid:264203)	Escherichia coli (taxid:469008)
	strain: ATCC 31821 / ZM4 / CP4 gene: tgt, ZMO0363 expression_system_strain: BL21CodonPlus(DE3)-RIPL expression_system_vector_type: Plasmid expression_system_plasmid: pPR-IBA2-ZM-V262T

Authors :

Neeb, M., Heine, A., Klebe, G.

Keywords :

Guanine Exchange Enzyme, preQ1, tRNA, Transferase-transferase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.887 Å )

Citation :

Creating a Resistance Model for TGT: The Effect of Mutations on Flexible lin-Benzoguanine Substituents

Neeb, M.,Heine, A.,Klebe, G.
To be Published

Chain :

UniProt :

P28720 (TGT_ZYMMO)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7- aminomethyl-7-carbaguanosine(34) in tRNA + guanine	2.4.2.29	HAMAP-Rule:MF_00168, PubMed:7665516
	-	HAMAP-Rule:MF_00168, PubMed:7665516
Cofactor:	Evidence:	Note:
Zn(2+)	ECO:0000255 \| HAMAP-Rule:MF_00168 ECO:0000269 \| PubMed:10413112 ECO:0000269 \| PubMed:11178905 ECO:0000269 \| PubMed:11921407 ECO:0000269 \| PubMed:12646024 ECO:0000269 \| PubMed:12909636 ECO:0000269 \| PubMed:12949492 ECO:0000269 \| PubMed:14523925 ECO:0000269 \| PubMed:19627989 ECO:0000269 \| PubMed:8654383 ECO:0000269 \| PubMed:8961936	Binds 1 zinc ion per subunit.

PDB ID: 4Q8O