Het-PDB Navi2 (PDB: 4Q2V)

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Ligands
Code	Name		Style	Show	Link
0XE	5,6-dihydroxy-4-oxo-2-phenyl-4h-chromen-7-yl beta-D-glucopyranosiduronic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4Q2V

Code :

4Q2V PDBj RCSB PDB PDBe

Header :

Hydrolase/Hydrolase inhibitor

Title :

Crystal Structure of Ricin A chain complexed with Baicalin inhibitor

Release Data :

2015-04-15

Compound :

mol_id	molecule	chains	synonym
1	Ricin	A	Ricin toxin chain A
	ec: 3.2.2.22 fragment: Ricin A chain

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Ricinus communis (taxid:3988)	Castor bean	Escherichia coli (taxid:562)
	expression_system_strain: BL21 DE3 expression_system_vector_type: plasmid expression_system_plasmid: pGex-6p-1

Authors :

Deng, X., Li, X., Dong, J., Chen, Y.

Keywords :

mixed alpha/beta structure, ribosome-inactivating, baicalin complex, ribosome, Hydrolase-Hydrolase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.198 Å )

Citation :

Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization.

Dong, J.,Zhang, Y.,Chen, Y. et al.
(2015) J.Biol.Chem. 290 : 12899 - 12907

Chain :

UniProt :

P02879 (RICI_RICCO)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
[Ricin A chain] Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.	3.2.2.22	-
	-	-

PDB ID: 4Q2V