Brand  (β version)

PDB ID: 4PX5

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Ligands
Code Name Style Show Link
2WZ N-[(R)-(2-amino-5-chloro-3-fluoropyridin-4-yl){7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl}methyl]cyclopropanesulfonamide PoSSuM
IOD Iodide ion PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
S6P D-sorbitol-6-phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4PX5   PDBj   RCSB PDB   PDBe
Header : sugar binding protein/inhibitor
Title : Human GKRP bound to AMG-0696 and Sorbitol-6-phosphate
Release Data : 2015-05-13
Compound :
mol_id molecule chains synonym
1 Glucokinase regulatory protein A,B GKRP, Glucokinase regulator
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GCKR
Authors : Jordan, S.R., Chmait, S.
Keywords : SIS domain containing protein, Regulatory protein - binds to and inhibits glucokinase, glucokinase, sugar binding protein-inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Discovery and Structure Guided Optimization of Diarylmethanesulfonamide Disruptors of GK-GKRP Binding

Pennington, L.D.,Bartberger, M.D.,Croghan, M.D.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : Q14397 (GCKR_HUMAN)
Reaction : -