Brand  (β version)

PDB ID: 4PV7

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Ligands
Code Name Style Show Link
CJP 1-[2-(2,4-dichlorophenyl)-1-(methylsulfonyl)-1h-indol-3-yl]methanamine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4PV7   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Cocrystal structure of dipeptidyl-peptidase 4 with an indole scaffold inhibitor
Release Data : 2015-03-18
Compound :
mol_id molecule chains synonym
1 Dipeptidyl peptidase 4 soluble form A,B ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Dipeptidyl peptidase IV soluble form
ec: 3.4.14.5
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human SPODOPTERA FRUGIPERDA  (taxid:7108)
gene: ADCP2, CD26, DPP4
expression_system_cell_line: SF9
expression_system_vector_type: baculovirus
Authors : Xiao, P., Guo, R., Huang, S., Cui, H., Ye, S., Zhang, Z.
Keywords : Beta-Propeller, Hydrolase, extrocellular side, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 3.24 Å )
Citation :

Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold

Xiao, P.,Guo, R.,Huang, S.  et al.
(2014)  Chin.Chem.Lett.  25 : 673 - 676

DOI: 10.1016/j.cclet.2014.03.047

Reaction

Chain : A, B
UniProt : P27487 (DPP4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. 3.4.14.5 PROSITE-ProRule:PRU10084, PubMed:10593948
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