Brand  (β version)

PDB ID: 4PV5

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CBW (3beta,5beta,14beta)-3-hydroxy-11-oxoolean-12-en-29-oic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4PV5   PDBj   RCSB PDB   PDBe
Header : LYASE/LYASE INHIBITOR
Title : Crystal structure of mouse glyoxalase I in complexed with 18-beta-glycyrrhetinic acid
Release Data : 2015-03-18
Compound :
mol_id molecule chains synonym
1 Lactoylglutathione lyase A,B Glyoxalase I, Aldoketomutase, Glx I, Ketone-aldehyde mutase, Methylglyoxalase, S-D-lactoylglutathione methylglyoxal lyase
ec: 4.4.1.5
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:562)
gene: Glo1
expression_system_strain: BL21(+)
Authors : Zhang, H., Zhai, J., Zhang, L.P., Zhao, Y.N., Li, C., Hu, X.P.
Keywords : LYASE-LYASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.3000 Å )
Citation :

Structural basis for 18-beta-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor

Zhang, H.,Huang, Q.,Zhai, J.  et al.
(2015)  Acta Pharmacol.Sin.  36 : 1145 - 1150

PubMed: 26279158
DOI: 10.1038/aps.2015.59

Reaction

Chain : A, B
UniProt : Q9CPU0 (LGUL_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
(R)-S-lactoylglutathione = glutathione + methylglyoxal 4.4.1.5 PubMed:18695250
right-to-left