Brand  (β version)

PDB ID: 4PPP

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Ligands
Code Name Style Show Link
FSV 5-[(E)-2-(3-fluoro-4-hydroxyphenyl)ethenyl]benzene-1,3-diol PoSSuM
Non-standard Residues
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Structure summary

Code : 4PPP   PDBj   RCSB PDB   PDBe
Header : PROTEIN BINDING
Title : Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Fluoro-Resveratrol
Release Data : 2014-05-07
Compound :
mol_id molecule chains synonym
1 Estrogen receptor A,B Estrogen receptor alpha, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1
fragment: ligand-binding domain (UNP residues 305-548)
mutation: Y537S
mol_id molecule chains synonym
2 Nuclear receptor coactivator 2 C,D NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2
fragment: receptor-interacting peptide (UNP residues 688-696)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ESR, ESR1, NR3A1
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Parent, A.A., Hughes, T.S., Pollock, J.A., Gjyshi, O., Cavett, V., Nowak, J., Garcia-Ordonez, R.D., Houtman, R., Griffin, P.R., Kojetin, D.J., Katzenellenbogen, J.A., Conkright, M.D., Nettles, K.W.
Keywords : nuclear hormone receptor, transcription factor, ligand-binding, nucleus, PROTEIN BINDING
Exp. method : X-RAY DIFFRACTION ( 2.686 Å )
Citation :

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network.

Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.  et al.
(2014)  Elife  3 : e02057 - e02057

PubMed: 24771768
DOI: 10.7554/eLife.02057

Reaction

Chain : A, B
UniProt : P03372 (ESR1_HUMAN)
Reaction : -
Chain : C, D
UniProt : Q15596 (NCOA2_HUMAN)
Reaction : -