Het-PDB Navi2 (PDB: 4POH)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
2VR	(2e,4e,6z,8e)-3,7-dimethyl-8-(8-methyl-3,4-dihydronaphthalen-1(2h)-ylidene)octa-2,4,6-trienoic acid				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 4POH

Code :

4POH PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Crystal structure of human Retinoid X Receptor alpha-ligand binding domain complex with 8-methyl UAB30 and the coactivator peptide GRIP-1

Release Data :

2014-06-18

Compound :

mol_id	molecule	chains	synonym
1	Retinoic acid receptor RXR-alpha	A	Nuclear receptor subfamily 2 group B member 1, Retinoid X receptor alpha
	fragment: Ligand Binding Domain, UNP residues 228-458

mol_id	molecule	chains	synonym
2	Nuclear receptor coactivator 2	B	NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2
	fragment: Coactivator peptide, UNP residues 686-698

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	strain: P19793 gene: NR2B1, RXRA, RXRA NR2B1 expression_system_vector_type: BL21(DE3)

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Xia, G., Smith, C.D., Muccio, D.D.

Keywords :

ligand binding domain, nuclear receptor, cancer, methyl substituted rexinoid, 8-methyl UAB30, TRANSCRIPTION

Exp. method :

X-RAY DIFFRACTION ( 2.3 Å )

Citation :

Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.

Atigadda, V.R.,Xia, G.,Desphande, A. et al.
(2014) J.Med.Chem. 57 : 5370 - 5380

PDB ID: 4POH