Brand  (β version)

PDB ID: 4PNN

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
JPZ Quinazolin-4(1h)-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4PNN   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of human Tankyrase 2 in complex with 4HQN.
Release Data : 2014-10-15
Compound :
mol_id molecule chains synonym
1 Tankyrase-2 A,B,C,D TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
ec: 2.4.2.30
fragment: PARP, catalytic domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TNKS2, PARP5B, TANK2, TNKL
Authors : Qiu, W., Lam, R., Romanov, V., Gordon, R., Gebremeskel, S., Vodsedalek, J., Thompson, C., Beletskaya, I., Battaile, K.P., Pai, E.F., Chirgadze, N.Y.
Keywords : poly(ADP-ribosylation) polymerase (PARP), TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.6500 Å )
Citation :

Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.

Qiu, W.,Lam, R.,Voytyuk, O.  et al.
(2014)  Acta Crystallogr.,Sect.D  70 : 2740 - 2753

PubMed: 25286857
DOI: 10.1107/S1399004714017660

Reaction

Chain : A, B, C, D
UniProt : Q9H2K2 (TNKS2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H(+). 2.4.2.30 PubMed:19759537, PubMed:21478859
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L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide - ECO:0000305
left-to-right
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide - ECO:0000305
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