PDB ID: 4PF9
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Code | Name | Style | Show | Link | |
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2Q6 | Methyl [(2s)-2-[4-({5-[4-({(2s)-2-[(3s)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}oxy)phenyl]-3-(quinolin-3-yl)propyl]carbamate | PoSSuM | |||
ZN | Zinc ion | PoSSuM |
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Download interaction data: 4PF9
Structure summary
Code : | 4PF9 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | Hydrolase/Hydrolase Inhibitor | ||||||||||||
Title : | Crystal structure of insulin degrading enzyme complexed with inhibitor | ||||||||||||
Release Data : | 2015-06-17 | ||||||||||||
Compound : |
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Authors : | Wang, Y., Guo, S. | ||||||||||||
Keywords : | HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.50 Å ) | ||||||||||||
Citation : |
Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
Durham, T.B.,Toth, J.L.,Klimkowski, V.J.
et al.
PubMed: 26085101 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P14735 (IDE_HUMAN) | ||||||||
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