Het-PDB Navi2 (PDB: 4P9Z)

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Ligands
Code	Name	Link
GOL	Glycerol	PoSSuM
ACT	Acetate ion	PoSSuM
CL	Chloride ion	PoSSuM

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine
02K	1-aminocyclohexanecarboxylic acid

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
NMI	3-(1-methyl-1h-indol-3-yl)propanoic acid
NH2	Amino group

Download interaction data: 4P9Z

Code :

4P9Z PDBj RCSB PDB PDBe

Header :

Signaling Protein/Antagonist

Title :

Grb2 SH2 complexed with a pTyr-Ac6c-Asn tripeptide

Release Data :

2014-06-18

Compound :

mol_id	molecule	chains	synonym
1	Growth factor receptor-bound protein 2	A	Adapter protein GRB2,Protein Ash,SH2/SH3 adapter GRB2

mol_id	molecule	chains
2	NMI-PTR-02K-ASN-NH2	B

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: GRB2, ASH expression_system_strain: SG13009 expression_system_vector_type: Plasmid expression_system_plasmid: PQE-60

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Clements, J.H., Martin, S.F.

Keywords :

Grb2 SH2, Cation-Pi Interaction, Signaling Protein-Antagonist complex

Exp. method :

X-RAY DIFFRACTION ( 1.80 Å )

Citation :

Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction.

Myslinski, J.M.,Clements, J.H.,Martin, S.F.
(2014) Bioorg.Med.Chem.Lett. 24 : 3164 - 3167

PDB ID: 4P9Z